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Nr2e3 Gene Detail
Summary
  • Symbol
    Nr2e3
  • Name
    nuclear receptor subfamily 2, group E, member 3
  • Synonyms
    photoreceptor-specific nuclear receptor, Pnr, RNR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346317
    NCBI Gene: 23958
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:59850054-59867942 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 32.35 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    543 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346317
 protein coding gene Chr9:59850054-59868117 (-)
129S1/SvImJ ENSMUSG00200033653
 protein coding gene Chr9:56968674-56976028 (-)
A/J ENSMUSG00195037269
 protein coding gene Chr9:56676241-56684270 (-)
AKR/J ENSMUSG00220025295
 protein coding gene Chr9:56826011-56834038 (-)
BALB/cJ ENSMUSG00180017624
 protein coding gene Chr9:56791025-56799052 (-)
C3H/HeJ ENSMUSG00175019319
 protein coding gene Chr9:56802942-56810969 (-)
C57BL/6NJ ENSMUSG00215021830
 protein coding gene Chr9:56784270-56792297 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032311
 protein coding gene Chr9:57142628-57160407 (-)
CAST/EiJ ENSTCUG00005018139
 protein coding gene Chr9:56724661-56732605 (-)
CBA/J ENSMUSG00210036958
 protein coding gene Chr9:56907232-56915269 (-)
DBA/2J ENSMUSG00185039599
 protein coding gene Chr9:56929628-56937655 (-)
FVB/NJ ENSMUSG00205040503
 protein coding gene Chr9:57245448-57253475 (-)
JF1/MsJ ENSUMUG00000043016
 protein coding gene Chr9:56952686-56960731 (-)
LP/J ENSMUSG00230037728
 protein coding gene Chr9:57168215-57176250 (-)
NOD/ShiLtJ ENSMUSG00190038312
 protein coding gene Chr9:56999751-57007778 (-)
NZO/HlLtJ ENSMUSG00225027426
 protein coding gene Chr9:57217633-57224983 (-)
PWK/PhJ ENSLUMG00010030897
 protein coding gene Chr9:56904902-56912961 (-)
SPRET/EiJ ENSMSPG00010021651
 protein coding gene Chr9:57957473-57964883 (-)
WSB/EiJ ENSIUOG00005039207
 protein coding gene Chr9:56407388-56415419 (-)



Homology
more
  • Human Ortholog
    NR2E3, nuclear receptor subfamily 2 group E member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR2E3, nuclear receptor subfamily 2 group E member 3
  • Synonyms
    ESCS, ESCS1, PNR, rd7, RNR, RP37
  • Links
    NCBI Gene ID: 10002
    UniProt: Q9Y5X4

  • Chr Location
    15q23; chr15:71792638-71818259 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nr2e3 mouse models; 2 with human NR2E3 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation exhibit rossettes and a reduced number of nuclei in the retinal outer nuclear layer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    877
  • Tissues
    205
  • cDNA Data
    50
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032292 Ensembl Gene Model | MGI Sequence Detail 17889 C57BL/6J ±  kb
    transcript ENSMUST00000034831 Ensembl | MGI Sequence Detail 2037 Not Applicable  
    polypeptide ENSMUSP00000034831 Ensembl | MGI Sequence Detail 395 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011403 photoreceptor-specific nuclear receptor
      (term hierarchy)
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR050274 Nuclear hormone receptor family NR2 subfamily
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 59
      cDNA 51
      Primer pair 6
      Other 2
      Antibodies 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1354383, MGI:2444464
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 46
      Diseases 2
      Gene Ontology 11
      Phenotypes 41
    • Earliest
      J:55816 Chang B, et al., A new mouse model of retinal dysplasia and degeneration (rd7). Invest Ophthalmol Vis Sci. 1998;39(4):S880 (Abstr.)
    • Latest
      J:386497 Hernandez-Nunez I, et al., Active DNA demethylation upstream of rod-photoreceptor fate determination is required for retinal development. PLoS Biol. 2025 Aug;23(8):e3003332
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/08/2026
    MGI 6.24     		The Jackson Laboratory